2005 HamdyBy: Shaheen Hamdy, MRCP, PhD
Hope Hospital, Salford, United Kingdom

Dr. Hamdy was the 2005 recipient of the IFFGD Junior Investigator, Clinical Science Research Award.

Dr. Hamdy has specific interest in the human brain-gut axis, in particular investigating the central neural control of human swallowing. Over the last three years, much of this work has revolved around the design and development of stimulation techniques for the treatment of swallowing recovery after dysphagic stroke.

A recent newer development has been the broadening of the human brain-gut studies to investigate the neural control of anal continence, and its abnormalities in fecal incontinence of unknown origin.


Dysphagia is a disorder characterized by difficulty swallowing. Swallowing is a highly complex process involving both nerve and muscle function. Swallowing involves more than transporting material from the mouth to the stomach for digestion. It also involves protection of the airway, rejection of harmful ingested substances, and the preparation of foods for digestion. We swallow on average once every minute and this is supplemented by the production of saliva.

Swallowing increases dramatically (6–8 times per minute) when we eat. When swallowing is disrupted, the consequences can be devastating, with complications such as malnutrition, entry (aspiration) of gastric or foreign material into the respiratory tract, and the associated problems of being unable to eat. The implications of swallowing difficulty are therefore of considerable medical importance to health workers of all disciplines.

Causes of adult neurogenic dysphagia

Difficulty in swallowing can occur as consequence of disease to either the organs and muscles involved in swallowing, or more commonly to the central nervous system controlling swallowing (neurogenic dysphagia). Anatomical problems, which disrupt swallowing, include many gastrointestinal disease processes from the mouth through to the first part of the small intestine (duodenum).

Doctors therefore will want to exclude any disease arising within the gut before making a diagnosis of dysphagia arising from the nervous system in someone presenting with symptoms of swallowing difficulty.

There are many neurological disorders and conditions that can disrupt swallowing. Examples include stroke, multiple sclerosis (MS), Parkinson’s disease, muscular dystrophies, and head injury. In addition, it is important to recognize that any pharmacological agent that alters neuromuscular function can produce dysphagia. However, the most common and arguably the most important cause of adult neurogenic dysphagia is stroke, the commonest form of neurological disorder seen on the medical wards.

Assessment of swallowing in neurogenic dysphagia

Dysphagia is arguably one of the most serious deficits in function that can result from neurological damage. The consequences may, at best, hinder a person’s recovery to normal function, and at worst, be life-threatening. In the hospital setting, patients admitted with neurological disorders should all have an assessment of swallowing as a part of routine clinical management. In many hospitals, this is done by the ward nursing staff.

To insure optimal therapy, it is essential that all staff who may be expected to perform a bedside swallowing examination are given adequate and appropriate training, as well as guidance on when to make relevant referrals to other medical professions including speech and language therapy, gastroenterology, and dietetics.

Complications of neurogenic dysphagia

Neurogenic dysphagia can lead to complications. Pulmonary aspiration (entry of foreign material into the lungs) is the easiest to identify. Aspiration may manifest itself suddenly or acutely as choking or coughing, respiratory distress, wheezing, gasping or gurgling, loss of voice quality, and rapid heart rate (tachycardia), or chronically (particularly in silent aspiration) as weight loss, hunger, excessive secretions, and refusal to eat. Less well clearly defined are the complications of dehydration and malnutrition.

Management of neurogenic dysphagia

In view of these complications, the management of neurogenic dysphagia becomes critical. Therapy may often include changes in diet, posture and food placement adjustments, as well as methods for altering the swallow reflex. At present, however, there is little data to support any of these approaches as producing benefit to dysphagic patients so their efficacy remains a matter of some controversy. If these methods are unhelpful, enteral feeding may be tried.

This involves providing food through a tube placed in the nose, stomach, or small intestine. However, while this may improve the nutritional status of the patient, there is some concern that the risk of pulmonary aspiration remains high, particularly among those with impaired cognitive ability.


Neurogenic dysphagia is a common, often under-diagnosed, problem of major clinical importance. Emphasis on early detection and appropriate treatment is crucial for the well being of the patient, in whom this condition can be distressing and life threatening. Well-trained health care professionals, especially nursing staff, are important if improvements in the management of patients with dysphagia are to be attained.

Currently, therapies such as enteral feeding, aimed at improving the patients’ nutrition provide a means of delivery. Nonetheless, this does not remove the risk of aspiration and as such the serious risk to these patients remains high.

Source: Adapted from IFFGD Publication Adult Neurogenic Dysphagia: Disorders and Conditions that Disrupt Swallowing by Shaheen Hamdy, MB, ChB, PhD, Honorary Consultant Gastroenterologist, Hope Hospital, Salford, M6 8HD, and the University of Manchester, United Kingdom.

Research Awards
2020 Award Recipients
Kyle Staller, MD
Christopher V. Almario, MD
Maria Raffaella Barbaro, PhD
2019 Award Recipients
Arpana Gupta, PhD
David Levinthal, MD, PhD
Ilan Koppen, MD, PhD
2018 Award Recipients
Amaranath Karunanayake, PhD
Katja Kovacic, MD
Cristina Martinez, PhD
Ans Pauwels, PhD
2013 Award Recipients
Enrico Corazziari, MD
Jan Tack, MD, PhD
Report from Gary Mawe, PhD: The Roles of Intestinal Nerves and Serotonin in Gut Function and Dysfunction
Ashley Blackshaw, PhD
Carlo Di Lorenzo, MD
Niranga Manjuri Devanarayana, MD
Report from Lukas Van Oudenhove, PhD: Solving the Biopsychosocial Puzzle in Functional Dyspepsia
Muriel Larauche, PhD
2011 Award Recipients
Report from Ronnie Fass, MD: Sleep and Gastroesophageal Reflux Disease (GERD)
Million Mulugeta, PhD
Adrian Miranda, MD
Samuel Nurko, MD
Sudarshan Jadcherla, MD
Shaman Rajindrajith, MD
2009 Award Recipients
Satish Rao, MD
Emeran Mayer, MD
Javier Santos, MD
Report from Martin Storr, MD, PhD: Functional Gastrointestinal Disorders: New Insights in Enteric Regulation
Report From Miguel Saps, MD: Functional Abdominal Pain in Children and Adolescents
2007 Award Recipients
Report from Bruce D. Naliboff, PhD: Symptom Based Psychology for Functional Gastrointestinal Disorders
Report from Magnus Simrén, MD, PhD: Irritable Bowel Syndrome: Searching for Underlying Causes
Report from Brennan M. R. Spiegel, MD, MSHS: Diagnostic Testing in Irritable Bowel Syndrome: Theory vs. Reality
Report from Sylvie Bradesi, PhD: Role of the Central Immune System in Functional Disorders
Paul E. Hyman, MD
Report from Miranda A. L. van Tilburg, PhD: Home Based Guided Imagery to Treat Pediatric Functional Abdominal Pain
Report from Fernando Azpiroz, MD, PhD: Understanding Intestinal Gas
2005 Award Recipients
Report from Yvette Tache, PhD: Stress and Irritable Bowel Syndrome: Unraveling the Code
Report from Shaheen Hamdy, MRCP, PhD: Adult Neurogenic Dysphagia -- Disorders and Conditions that Disrupt Swallowing
Report from Michael A. Pezzone, MD, PhD: Chronic Pelvic Pain and the Overlap of Pelvic Pain Disorders
Report from Bridget R. Southwell, PhD: Research into Treatment-Resistant Constipation in Children
Report from Rachel Rosen, MD, MPH: Symptoms Arising from Non-Acid Reflux in Children
2003 Award Recipients
Report from William E. Whitehead, PhD: Summary of Clinical Research Activities
Jyoti N. Sengupta, PhD
Report from Caroline Elder Danda, PhD: Biopsychosocial Perspectives on Assessment and Treatment
Report from Terry Buchmiller-Crair, MD: Using the Fetal Gastrointestinal Tract to Overcome Neonatal Disease
Report from Dan L. Dumitrascu, MD, PhD: The Psychosocial Adjustment to Illness in Irritable Bowel Syndrome
Report from Klaus Bielefeldt, MD, PhD: Understanding Pain and Discomfort in Functional GI Disorders
Research Grants
IFFGD Competitive Grants
2014 IFFGD Idiopathic Gastroparesis Research Grants
Leo Cheng, PhD
Braden Kuo, MD, MSc
Richard McCallum, MD
2008 IFFGD Competitive Research Grants
IFFGD Noncompetitive Grants
Other Research Grant Opportunities
Funding Research
Need for Funding Research
How to Make a Difference
The State of Research at NIH & NIDDK
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Guide to Randomized Clinical Trials
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