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Clinical studies/trials are important in finding more and better treatments. Participation in clinical studies or trials offers one way to help advance research into gastrointestinal (GI) disorders. Here is a list of clinical studies, in adults and children, that are seeking participants. A description of the study purpose and contact information is included.

 

All Functional GI Disorders

Functional GI Disorders Registry

Purpose of study: Participants sought for inclusion in a registry of individuals with functional GI disorders, in order to acquire a pool of individuals for contact for future studies.

Sponsor: Macquarie University, Australia

Participation: Any individual with a functional GI disorder and some level of abdominal discomfort is invited to participate.

About the study: Individuals included in the registry may be invited to participate in future research studies conducted by online questionnaire.

Contact: For more information, visit www.mqedu.qualtrics.com or This email address is being protected from spambots. You need JavaScript enabled to view it..

Verified August 2017

 

Seeking Participants for Online Study on Cognitive Mediators of Bowel Discomfort 

Purpose of study: The aims of this project are to explore how psychological well-being may impact upon bowel discomfort and if cognitive processes (gastrointestinal-focused anxiety, pain, and acceptance toward symptoms) also influence this relationship.

Sponsor: Swinburne University, Australia

Participation: Eligible male and female individuals 18 years old and older. 

About the study: Individuals included in the study will be asked about common symptoms associated with mental health concerns and how they may influence gastrointestinal discomfort and quality of life.

Participants can elect to be entered in a raffle to win one of four $100 Amazon gift cards.

Contact: For more information and to participate, visit www.swinburnefhad.au or contact Dr. Simon Knowles. Email: This email address is being protected from spambots. You need JavaScript enabled to view it..

Added August 2017

 

Cyclic Vomiting Syndrome (CVS)

Two Online Studies on Cyclic Vomiting Syndrome (CVS)

Purpose of study 1: A research study is being conducted in order to learn what the experiences are regarding two nutritional supplements, co-enzyme Q10 (also known as "Co-Q") and L-carnitine (Carnitor), and one medication, amitriptyline (Elavil), for the treatment of CVS. 

Sponsor: Eligible individuals of any age previously diagnosed with CVS

Participation: Eligible children aged 7 to 12 who have experienced at least 3 episodes of unexplained abdominal pain over a 3 month period.

Link: Click here to begin the survey

Purpose of study 2: CVSA is undertaking a formal process of educating Emergency Room physicians and para-professionals about CVS. They are asking for your participation in a brief survey in order to help plan this educational approach. 

Sponsor: Cyclic Vomiting Syndrome Association (CVSA) and Children's Hospital of Wisconsin

Participation: Eligible individuals of any age who have ever visited the emergency room for the care of CVS either as a patient or as a caregiver to a patient

Link: Click here to begin the survey

Verified August 2017

 

Gastroparesis

NIH Gastroparesis Clinical Research Consortium  (GpCRC) Registry

Purpose of study: The GpCRC is recruiting patients for their gastroparesis registry. Individuals with gastroparesis who sign up for the registry may be contacted about participating in trials or surveys about gastroparesis. The GpCRC is a network of medical centers, sponsored by the National Institutes of Health (NIH), Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), established to improve our understanding of the cause and natural course of gastroparesis and to advance the diagnosis and treatment of this disorder.

Sponsor: NIDDK

Participation: Eligible male and female individuals aged 18 and older who have been previously diagnosed with gastroparesis and delayed gastric emptying

Contacts & Registration: See the Clinicaltrials.gov listing for information on locations and contacts.

Verified August 2017

 

Rare Genetic Diseases

Recruiting Individuals with Rare Genetic Disorders

Purpose of study: In an effort to help researchers working to understand gastrointestinal motility diseases like mitochondrial nueorgastrointestinal encephalopathy, blood samples and clinical data from individuals with rare genetic diseases are being collected. The samples are made anonymous and shared with scientists to use in their research for treatments and causes. Families living outside the US are also welcome to donate a sample to the repository.

Sponsors: The National Institute of General Medical Sciences (NIGMS) Human Genetic Cell Repository Program and Coriell Institute for Medical Research

Participation: Eligible individuals with an inherited genetic disease or chromosomal abnormality

Contacts: Families who want to participate in this research effort can can read more about the Repository and donation process here, or can contact the NIGMS Human Genetic Cell Repository genetic counselor, Tara Schmidlen, MS, CGC, for postage-paid sample collection kits and the necessary paperwork: Phone: 856-757-4822, Email: This email address is being protected from spambots. You need JavaScript enabled to view it..

 Verified August 2017

 

Pediatric Gastrointestinal Disorders

Participants Needed for Study on the Defecation Habits of Young Children

Purpose of study: The purpose of this research study is to learn more about the relationship between children's bowel habits and the way they react to sensory input. Some children are very sensitive to the way things feel, smell, and sound, and this might interfere with their willingness to use the toilet for a bowel movement. Eligible participants will be asked to complete 4 questionnaires with questions related to these reactions to sensation and bowel habits of children.

Sponsor: University of Newcastle

Participation: Parents of children between ages 3 and 6 years. The study will include children with or without functional defecation issues who may or may not also have a diagnosis of ADHD or autism. Excluded from the study are children with organic defecation issues and/or a diagnosis other than ADHA or autism. 

Contact: Enter your information on this online contact form to receive additional study information or contact Isabelle Beaudry-Bellefeuille at This email address is being protected from spambots. You need JavaScript enabled to view it.

Added August 2017

 

Parents or Guardians of Children with Feeding Disorders to Participate in an Online Survey 

Purpose of study: This online survey study aims to gain a better understanding of the financial burden on parents and guardians of children with feeding disorders. The investigators are interested in gathering information about the experiences and costs related to being a parent or guardian of a child with a feeding disorder. The survey may take up to 20 minutes to complete.

Sponsor: Feeding Matters

Participation: Parents or guardians of a child with a feeding disorder are invited to participate. 

Contact: For more information or to participate, go to www.feedingmatters.org/economic-impact-study. Or, contact Dr. Melissa Kovacs. Phone: 602-492-1406, Email: This email address is being protected from spambots. You need JavaScript enabled to view it..  

Added August 2017

 

Celiac Disease

Participants Needed for POWER-C Study

Purpose of study: The POWER-C (Promotion of Optimal Well-Being, Education, and Regulation for Celiac Disease) study is a free online, evidence-based program for people newly diagnosed and/or struggling with celiac disease. The purpose of the study is to examine the impact of an 8-week online program containing 4 modules to be completed bi-weekly in adults with celiac disease. Participants will be asked to complete online questionnaires at 4 time points.

Sponsor: University of Calgary

Participation: Adult individuals (ages 18+) located in North America diagnosed with celiac disease (blood test and/or biopsy). Eligible individuals are required to follow a strict gluten-free diet to participate.

Contact: Dr. Justine Dowd. Phone: 1-403-210-8482. Email: This email address is being protected from spambots. You need JavaScript enabled to view it.. For additional information: https://www.cureceliacdisease.org/wp-content/uploads/power_c.pdf.

Verified August 2017

 

Hirschsprung's Disease

Participants Sought for Genetic Study of Hirschsprung's Disease

Purpose of study: Dr. Aravinda Chakravarti's laboratory at Johns Hopkins University has been investigating the genetics of Hirschsprung's disease for more than twenty years. The purpose of this study is to continue the search for genes involved in Hirschsprung's disease and to further characterize the known genes and the interactions between them. The study will hopefully lead to a better understanding of the genetics of Hirschsprung's disease and improve diagnosis, treatment, and genetic counseling.

Study volunteers and their parents (as available) are asked to complete a medical/family history questionnaire, provide access to select medical records, and submit to blood or cheek swab/saliva samples. If interested, a kit containing all the materials necessary to participate can be sent at no cost to the volunteer.

Sponsor: Johns Hopkins University

Participation: Eligible individuals with Hirschsprung's disease and their family members.

Contact: Courtney Berrios. Phone: 410-502-7541, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.. You can also visit our study website at: www.aravindachakravartilab.org/pro/Hirschsprung_Study.html

Verified August 2017

 

Chronic Intestinal Pseudo-Obstruction

Diagnostic Gene Studies for Chronic Intestinal Pseudo-Obstruction

A mutation in a gene transmitted through a dominant mode of inheritance (an affected person having a 50% risk of passing the disorder to each of his or her children) can cause chronic intestinal pseudo-obstruction (CIPO), with or without frequent bladder involvement. The disorder can also occur due to a new mutation. Thus far, the most important gene discovered with mutations is the ACTG2 gene.

A second gene is being sought by the Center for Human Genetics. Families who wish to participate in this research effort can email Aubrey Milunsky, MD at This email address is being protected from spambots. You need JavaScript enabled to view it. for details.

Verified August 2017

 

Irritable Bowel Syndrome (IBS)

Seeking Participants for Nutrition Counseling Study for IBS

Purpose of study: This study involves free nutrition sessions with a skilled IBS-specializing dietitian.

Sponsor: UCLA Oppenheimer Family Center for Neurobiology of Stress

Participation: Eligible male and female individuals ages 18 and older with a diagnosis of IBS with diarrhea or diarrhea with constipation (IBS-D or IBS-M). To participate, individuals must not have tried the low FODMAP diet before.

Contact: For more information, visit www.uclacns.org/patients/clinical-research or call (310) 206-1656.

Added August 2017.

 

Irritable Bowel Syndrome Outcome Study (IBSOS) Seeking Participants

Purpose of study: The purpose of this study is to test the efficacy of a behavioral self-management treatment for irritable bowel syndrome (IBS). The long-term goal of the project is to develop an effective, self-administered behavioral treatment program that can enhance the quality of patient care, improve clinical outcomes, and decrease the economic and personal costs of IBS.

Sponsor: University of Buffalo Behavioral Medicine Clinic

Participation: Dependent on screening and eligibility criteria

Contact: For more information, visit http://ubbmc.buffalo.edu/research/ibsos.php or call (716) 898-4458. 

Verified August 2017

 

Participants Sought for IBS Study Exploring the Brain-Gut Connection

Purpose of study: The purpose of this study is to learn more about how IBS develops, which may lead to the development of diagnostic tests and treatments.

Sponsor: UCLA Oppenheimer Family Center for Neurobiology of Stress

Participation: Men and women between the ages of 18 and 55 who suffer with or without IBS symptoms.

About the study: The study will consist of 2-3 visits during which a baseline (clinical assessment, questionnaires, saliva, blood, stool, and urine samples) will be taken in addition to a brain MRI and a DEXA scan and blood draw.

Participants will be compensated up to $150

Contact: For more information, visit www.uclacns.org/patients/clinical-research or call (310) 206-8545.

Verified August 2017

 

Participants with and without IBS Recruited for Hormone Challenge Study

Purpose of study: The purpose of this study is to compare certain components found in the saliva, blood, urine, and stool and responses to stressors between IBS patients and healthy adults.

Sponsor: UCLA Oppenheimer Family Center for Neurobiology of Stress

Participation: Men and women between the ages of 18 and 55 who suffer with or without IBS symptoms.

About the study: The study will consist of 3 visits where eligible participants will undergo medical and psychological evaluation, fill out questionnaires, and provide saliva, blood, urine, and stool samples. Participants will also complete 2 hormone challenge tests (i.e. Acthrel and Cortrosyn) and serial blood collections on separate days.

Participants will be compensated up to $250

Contact: For more information, visit www.uclacns.org/patients/clinical-research or call (310) 206-1719.

 Verified August 2017

 

Participants with and without IBS Needed for Colon Examination Study

Purpose of study: The purpose of this study is to compare certain components found in the saliva, blood, urine, stool, and tissue from the wall of the large intestine (colon) and responses to stressors between IBS patients and healthy adults.

Sponsor: UCLA Oppenheimer Family Center for Neurobiology of Stress

Participation: Men and women between the ages of 18 and 55 who suffer with or without IBS symptoms.

About the study: The study will consist of 2 visits where eligible participants will undergo medical and psychological evaluation, fill out questionnaires, and provide saliva, blood, urine, and stool samples. Participants will also receive a free colon examination (flexible sigmoidoscopy).

Participants will be compensated up to $225

Contact: For more information, visit www.uclacns.org/patients/clinical-research or call (310) 206-1719.

Verified August 2017

 

Participants with IBS Sought for an Imaging Study on the Brain, the Gut, and the Microbiome

Purpose of study: The purpose of this study is to examine brain networks at rest in chronic pain conditions compared to healthy controls.

Sponsor: UCLA Oppenheimer Family Center for Neurobiology of Stress

Participation: Right-handed men and women between the ages of 18 and 55 who have been diagnosed with IBS. Participants cannot currently be pregnant and cannot have a significant neurological or psychological medical history.

About the study: Participation involves a screening visit, an MRI, and one stool sample.

Participants will be compensated up to $100 and receive a digital picture of their brain.

Contact: For more information, visit www.uclacns.org/patients/clinical-research or call (310) 825-5255.

Verified August 2017

 

Participants Sought for Study on Complementary Approaches to the Treatment of IBS

Purpose of study: The purpose of this study is to find a complementary treatment to help Irritable Bowel Syndrome (IBS) patients in need of relief.

About The Study: The length of this study will be three weeks long, with a short online intervention everyday to help individuals deal with their body’s reactions to their environments. Participants will have additional surveys to assess their overall state at the beginning of the study, at the end of the three week intervention, and again at six weeks for a follow-up.

Participation: Eligible individuals between the ages of 18 – 65 years of age who are experiencing pain or discomfort associated with their gut. Cannot be smokers or have an inflammatory bowel disease.

How to Sign Up: http://bit.ly/IBS_study

There will be a $15 Target gift card for first 30 participants upon completion of study.

Study Contact: Jenna N. Ray,  Health Psychologist. Phone: (919) 257 – 7291, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Verified August 2017

 

Seeking IBS Patients and Their Partners

Purpose of study: IBS patients know that their intimate relationships can have an effect on how they are feeling. However, it is not known whether agreement or disagreement regarding issues such as cause of IBS, beliefs about illness, harmony in relationship may have an effect on IBS symptoms. This is an important question that may affect the way IBS is treated.

About the study: Our study requires patients to complete 5 brief questionnaires and partners to complete 3 brief questionnaires. Patients and partners will be contacted separately and results will be strictly confidential with no way of identifying subjects.

Participant couples will receive an IBS-related book as a gift for their participation.

Contact: Please contact This email address is being protected from spambots. You need JavaScript enabled to view it., and links to a secure survey site will be sent individually to both patient and partner, with instructions. From that point on, no identifying information will be stored.

Verified February 2015

 

Online Survey Aimed at Understanding Episodes of IBS

Purpose of study:  This online survey has been constructed in order to compile written reports of IBS episodes and help the researchers gain a better understanding of the symptoms and experiences people have during an IBS episode.

About the study: Have you been diagnosed with IBS? If so, you are eligible to help out with a one-time online survey that may take up to 20 minutes to complete. This survey is completely confidential and you will not be asked any identifying information.

Sponsor: University of North Carolina – Chapel Hill and the Drossman Center for Education and Practice of Biopsychosocial Care

To participate: Click here to begin.

Study Contact: Dr. Stephan Weinland. Phone: (919) 843 – 4422, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Verified August 2017 

 

Online Survey on Symptoms in IBS

Purpose of study:  One of the most important questions for individual patients with irritable bowel syndrome (IBS) is how long the symptoms will continue. A number of factors are thought to be important in determining recovery from IBS but so far studies have not been big enough to be certain of the results. The aim of this world-wide survey will be to gather together the experience of a large number of patients with irritable bowel syndrome, both those in whom it has begun with an infection and those in whom it has not. By comparing these we will be able to understand more about both conditions.

About the study: This is a web-based survey designed to help learn more about irritable bowel syndrome in order that physicians might better plan treatments and management. Of particular interest is how symptoms develop over time. The study is multilingual and is currently available in nine languages.

Sponsor: European Gastroenterology Federation

To participate: Go to www.postinfectious-ibs.eu and click on your language of choice to complete the simple online questionnaire.

Verified August 2017

 

Accidental Bowel Leakage (or Incontinence)

Seeking Participants with Diarrhea and Urge Predominant Fecal Incontinence

Purpose of study: This 12 week Phase III study will assess the efficacy and safety of a combination clonidine and colesevelam compared with placebo in women with diarrhea and urge predominant fecal incontinence.

Sponsor: NIH and Mayo Clinic

Participation: Women aged 18 to 80 years of age with diarrhea and urge predominant or combination (urge and passive) fecal incontinence for at least one year duration.

Contact: Kelly Feuerhak (email: This email address is being protected from spambots. You need JavaScript enabled to view it.or phone: 507-255-6802), Subhankar Chakraborty (email: This email address is being protected from spambots. You need JavaScript enabled to view it. or phone: 507-255-4803), or Adil Bharucha (email: This email address is being protected from spambots. You need JavaScript enabled to view it. or phone: 507-284-2687). Refer to this study by its ClinicalTrials.gov identifier NCT02628626.

Verified August 2017

 

Seeking Participants to Help Validate a Symptom Diary for Fecal Incontinence

Purpose of study: The UNC Center for Functional GI & Motility Disorders is in the process of validating a symptom diary that will be used in a future research study. The aim of this portion of the study is to determine if people who do and do not have accidental bowel leakage, also known as fecal incontinence, understand the diary questions and can provide feedback on the diary.

Participation in this research study will involve filling out a daily diary for four weeks and answering questionnaires before and after the research study. This research study will involve two in-person visits that will last up to 60 minutes each.

Participants can earn up to $100 for participation in this research study.

Sponsor: UNC Center for Functional GI & Motility Disorders

Participation: Individuals both with and without fecal incontinence.

Contact: Stefanie Twist (email: This email address is being protected from spambots. You need JavaScript enabled to view it.or phone: 919-843-6961)

Added September 2017

 

Colorectal Cancer

Seeking Participants with History of Cancer to Participate in Lifestyle and Quality of Life Study

Purpose of study: The goal of this anonymous online survey study is to gain a better understanding of how to support quality of life in cancer. The survey will include questions on lifestyle, demographics, health history, physical and psychological functioning, and healthcare preferences. The survey will take approximately 10 minutes to complete.

Sponsor: Tulane University 

Participation: Adults ages 18 and older with a past or present cancer diagnosis.

Contact: For more information or to participate go to www.tulanestudy.com/ or contact Laura Perry (email: This email address is being protected from spambots. You need JavaScript enabled to view it.). 

Added August 2017

Research Awards
2013 Award Recipients
Enrico Corazziari, MD
Jan Tack, MD, PhD
Gary Mawe, PhD
Ashley Blackshaw, PhD
Carlo Di Lorenzo, MD
Niranga Manjuri Devanarayana, MD
Report from Lukas Van Oudenhove, PhD: Solving the Biopsychosocial Puzzle in Functional Dyspepsia
Muriel Larauche, PhD
2011 Award Recipients
Report from Ronnie Fass, MD: Sleep and Gastroesophageal Reflux Disease (GERD)
Million Mulugeta, PhD
Adrian Miranda, MD
Samuel Nurko, MD
Sudarshan Jadcherla, MD
Shaman Rajindrajith, MD
2009 Award Recipients
Satish Rao, MD
Emeran Mayer, MD
Javier Santos, MD
Report from Martin Storr, MD, PhD: Functional Gastrointestinal Disorders: New Insights in Enteric Regulation
Report From Miguel Saps, MD: Functional Abdominal Pain in Children and Adolescents
2007 Award Recipients
Report from Bruce D. Naliboff, PhD: Symptom Based Psychology for Functional Gastrointestinal Disorders
Report from Magnus Simrén, MD, PhD: Irritable Bowel Syndrome: Searching for Underlying Causes
Report from Brennan M. R. Spiegel, MD, MSHS: Diagnostic Testing in Irritable Bowel Syndrome: Theory vs. Reality
Report from Sylvie Bradesi, PhD: Role of the Central Immune System in Functional Disorders
Paul E. Hyman, MD
Report from Miranda A. L. van Tilburg, PhD: Home Based Guided Imagery to Treat Pediatric Functional Abdominal Pain
Report from Fernando Azpiroz, MD, PhD: Understanding Intestinal Gas
2005 Award Recipients
Report from Yvette Tache, PhD: Stress and Irritable Bowel Syndrome: Unraveling the Code
Report from Shaheen Hamdy, MRCP, PhD: Adult Neurogenic Dysphagia -- Disorders and Conditions that Disrupt Swallowing
Report from Michael A. Pezzone, MD, PhD: Chronic Pelvic Pain and the Overlap of Pelvic Pain Disorders
Report from Bridget R. Southwell, PhD: Research into Treatment-Resistant Constipation in Children
Report from Rachel Rosen, MD, MPH: Symptoms Arising from Non-Acid Reflux in Children
2003 Award Recipients
Report from William E. Whitehead, PhD: Summary of Clinical Research Activities
Jyoti N. Sengupta, PhD
Report from Caroline Elder Danda, PhD: Biopsychosocial Perspectives on Assessment and Treatment
Report from Terry Buchmiller-Crair, MD: Using the Fetal Gastrointestinal Tract to Overcome Neonatal Disease
Report from Dan L. Dumitrascu, MD, PhD: The Psychosocial Adjustment to Illness in Irritable Bowel Syndrome
Report from Klaus Bielefeldt, MD, PhD: Understanding Pain and Discomfort in Functional GI Disorders
Research Grants
IFFGD Competitive Grants
2014 IFFGD Idiopathic Gastroparesis Research Grants
Leo Cheng, PhD
Braden Kuo, MD, MSc
Richard McCallum, MD
2008 IFFGD Competitive Research Grants
IFFGD Noncompetitive Grants
Other Research Grant Opportunities
Funding Research
Need for Funding Research
How to Make a Difference
The State of Research at NIH & NIDDK
Clinical Trials & Studies
IBS Studies
Guide to Randomized Clinical Trials
Industry Sponsored Clinical Trials and Studies
NIH/Other Sponsored Clinical Trials and Studies

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