Historical perspective on the long-term safety of proton pump inhibitors (PPIs) for gastroesophageal reflux disease (GERD)
For decades, it has been known that stomach acid can cause heartburn when it refluxes back up in to the esophagus. Nearly all remedies that neutralize or suppress stomach acid relieve the symptoms of acid reflux. Millions of people have taken these medications for long periods with great benefit and seemingly few side effects. This article takes a look at several challenges to the safety of acid suppressing medications that have appeared in medical and popular literature.