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Elobixibat


Elobixibat is a first-in-class compound under investigation for treatment of chronic idiopathic constipation (CIC), and for irritable bowel syndrome with constipation (IBS-C). It works by reducing bile acid absorption in the small intestine. This stimulates bowel movements by increasing fluid secretions and motility in the colon.

In Phase 2b clinical trials, elobixibat (formerly A3309) has been evaluated in patients in the U.S. and Europe for the treatment of CIC. The studies demonstrated clinically meaningful, statistically significant, and dose-dependent improvements. These included increased stool frequency and improved constipation-related symptoms such as straining, stool consistency, and bloating maintained over 8 weeks of treatment.

Elobixibat is due to enter Phase 3 trials for the CIC indication and Phase 2b trials for the IBS-C indication shortly.

 

What are Phases?

Treatment trials or studies are in phases:

  • Phase 1 tests a new drug or treatment in a small group to evaluate its safety, determine a safe dosage range, and identify side effects;
  • Phase 2 expands the study to a larger group of people to see if it is effective and to further evaluate its safety;
  • Phase 3 expands the study to an even larger group of people to confirm its effectiveness, monitor side effects, and collect information that will allow the drug or treatment to be used safely.
Last modified on January 25, 2013 at 10:59:07 AM